(Oligo)metastasis as a Spectrum of Disease

Abstract Cancer metastasis is the leading cause of cancer-related mortality, and most patients with metastases from solid tumors have historically been considered incurable. Here, we discuss evolution our understanding oligometastatic state an emphasis on view that cancer represents a spectrum disease. We highlight several recently published prospective clinical trials demonstrating improvements in cancer-specific outcomes utilization metastasis-directed local therapies. biological aspects oligometastases, including genetic, epigenetic, immune determinants metastatic spectrum. Finally, propose future considerations regarding trial design for